English K et al. Leucine partially protects muscle mass and function during bed rest in middle-aged adults. Am J Clin Nutr. 2016; 103: 465-73. PMID: 26718415. Link
Phillips S, Paddon-Jones D, & Layman D. Optimizing adult protein intake during catabolic health conditions. Advances in Nutrition. 2020;11(4):S1058-S1069. PMID: 32666115. Link
Churchward-Venne T et al. Supplementation of a suboptimal protein dose with leucine or essential amino acids: Effects on myofibrillar protein synthesis at rest and following resistance exercise in men. J Physiol. 2012;590(11):2751-65. PMID: 22451437. Link
Drover JW et al. Perioperative use of arginine-supplemented diets: a systematic review of the evidence. J Am Coll Surg. 2011;212(3):385-99, 399.e1. PMID: 21247782. Link
Carr AC, & Maggini S. Vitamin C and immune function. Nutrients. 2017; 9(11):1211. PMID: 29099763. Link
Gorter EA, Krijnen P, & Schipper IB. Vitamin D status and adult fracture healing. J Clin Orthop Trauma. 2017;8(1):34-37. PMID: 28360494. Link
Roberts JL & Drissi H. Advances and promises of nutritional influences on natural bone repair. J Orthop Res. 2020;38(4):695-707. PMID: 31729041. Link
Chasapis CT et al. Zinc and human health: an update. Arch Toxicol. 2012;86(4):521-34. PMID: 22071549. Link
Murphy CH et al. Leucine supplementation enhances integrative myofibrillar protein synthesis in free-living older men consuming lower- and higher-protein diets: a parallel-group crossover study. Am J Clin Nutr. 2016;104(6):1594-1606. PMID: 27935521. Link
Dougherty KA, Dilisio MF, & Agrawal DK. Vitamin D and the immunomodulation of rotator cuff injury. J Inflamm Res. 2016 Jun 14;9:123-31. PMID: 27366101. Link
Hendrickson NR et al. Conditionally essential amino acid supplementation reduces postoperative complications and muscle wasting after fracture fixation: A randomized controlled trial. J Bone Joint Surg Am. 2022;104(9):759-766. PMID: 35286282. Link
Aanandhi M VJ. Enteral/oral glutamine supplementation in patients following surgery and accidental injury. Asian J Pharm Clin Res.2017; 10(3): 477-479. Link
Schneider KL & Yahia N. Effectiveness of arginine supplementation on wound healing in older adults in acute and chronic settings: A systematic review. Adv Skin Wound Care. 2019;32(10):457-462. PMID: 31498170. Link
Ekinci O et al. Effect of Calcium β-Hydroxy-β-Methylbutyrate (CaHMB), Vitamin D, and protein supplementation on postoperative immobilization in malnourished older adult patients with hip fracture: A randomized controlled study. Nutr Clin Pract. 2016;31(6):829-835. PMID: 26965178. Link
PERFORM
Fança-Berthon P, Tenon M, Bouter-Banon SL, Manfré A, Maudet C, Dion A, Chevallier H, Laval J, van Breemen RB. Pharmacokinetics of a Single Dose of Turmeric Curcuminoids Depends on Formulation: Results of a Human Crossover Study. J Nutr. 2021 Jul 1;151(7):1802-1816. doi: 10.1093/jn/nxab087. PMID: 33877323; PMCID: PMC8245892. Link
Daily JW, Yang M, Park S. Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food. 2016 Aug;19(8):717-29. doi: 10.1089/jmf.2016.3705. PMID: 27533649; PMCID: PMC5003001. Link
Wang Z, Singh A, Jones G, Winzenberg T, Ding C, Chopra A, Das S, Danda D, Laslett L, Antony B. Efficacy and Safety of Turmeric Extracts for the Treatment of Knee Osteoarthritis: a Systematic Review and Meta-analysis of Randomised Controlled Trials. Curr Rheumatol Rep. 2021 Jan 28;23(2):11. doi: 10.1007/s11926-020-00975-8. PMID: 33511486. Link
Auddy B et al. A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study. J Am Nutr Assoc. 2008;8(1):2-6. Link
Ramakanth GS, Uday Kumar C, Kishan PV, Usharani P. A randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint pain. J Ayurveda Integr Med. 2016 Jul-Sep;7(3):151-157. doi: 10.1016/j.jaim.2016.05.003. Epub 2016 Sep 16. PMID: 27647541; PMCID: PMC5052364. Link
Suhett, L. G., de Miranda Monteiro Santos, R., Silveira, B. K. S., Leal, A. C. G., de Brito, A. D. M., de Novaes, J. F., & Lucia, C. M. D. (2020). Effects of curcumin supplementation on sport and physical exercise: a systematic review. Critical Reviews in Food Science and Nutrition, 61(6), 946–958. Link
Fernández-Lázaro, D., Mielgo-Ayuso, J., Seco Calvo, J., Córdova Martínez, A., Caballero García, A., & Fernandez-Lazaro, C. I. (2020). Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population: A Systematic Review. Nutrients, 12(2), 501. Link
Bonilla, D. A., Moreno, Y., Gho, C., Petro, J. L., Odriozola-Martínez, A., & Kreider, R. B. (2021). Effects of Ashwagandha (Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis. Journal of Functional Morphology and Kinesiology, 6(1), 20. Link
REGENERATE
Rathmacher JA, Pitchford LM, Khoo P, Angus H, Lang J, Lowry K, Ruby C, Krajek AC, Fuller JC, Sharp RL. Long-term Effects of Calcium β-Hydroxy-β-Methylbutyrate and Vitamin D3 Supplementation on Muscular Function in Older Adults With and Without Resistance Training: A Randomized, Double-blind, Controlled Study. J Gerontol A Biol Sci Med Sci. 2020 Oct 15;75(11):2089-2097. doi: 10.1093/gerona/glaa218. PMID: 32857128; PMCID: PMC7566440. Link
Hsieh LC, Chien SL, Huang MS, Tseng HF, Chang CK. Anti-inflammatory and anticatabolic effects of short-term beta-hydroxy-beta-methylbutyrate supplementation on chronic obstructive pulmonary disease patients in intensive care unit. Asia Pac J Clin Nutr. 2006;15(4):544-50. PMID: 17077073. Link
Zanchi NE, Gerlinger-Romero F, Guimarães-Ferreira L, de Siqueira Filho MA, Felitti V, Lira FS, Seelaender M, Lancha AH Jr. HMB supplementation: clinical and athletic performance-related effects and mechanisms of action. Amino Acids. 2011 Apr;40(4):1015-25. doi: 10.1007/s00726-010-0678-0. Epub 2010 Jul 6. PMID: 20607321. Link
Buford TW, Cooke MB, Redd LL, Hudson GM, Shelmadine BD, Willoughby DS. Protease supplementation improves muscle function after eccentric exercise. Med Sci Sports Exerc. 2009 Oct;41(10):1908-14. doi: 10.1249/MSS.0b013e3181a518f0. PMID: 19727022. Link
Durkalec-Michalski K, Jeszka J, Podgórski T. The Effect of a 12-Week Beta-hydroxy-beta-methylbutyrate (HMB) Supplementation on Highly-Trained Combat Sports Athletes: A Randomised, Double-Blind, Placebo-Controlled Crossover Study. Nutrients. 2017 Jul 14;9(7):753. doi: 10.3390/nu9070753. PMID: 28708126; PMCID: PMC5537867. Link
Kleessen B, Schwarz S, Boehm A, Fuhrmann H, Richter A, Henle T, Krueger M. Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers. Br J Nutr. 2007 Sep;98(3):540-9. doi: 10.1017/S0007114507730751. Epub 2007 Apr 20. PMID: 17445348. Link
Engelen MPKJ, Deutz NEP. Is β-hydroxy β-methylbutyrate an effective anabolic agent to improve outcome in older diseased populations? Curr Opin Clin Nutr Metab Care. 2018 May;21(3):207-213. doi: 10.1097/MCO.0000000000000459. PMID: 29406417; PMCID: PMC5882564. Link
TOTAL KNEE ARTHROPLASTY
Dreyer HC et al. Essential amino acid supplementation in patients following total knee arthroplasty. J Clin Invest. 2013; 23(11):4654-66. PMCID: PMC3809795. Link
Dreyer HC et al. Essential amino acid supplementation mitigates muscle atrophy after total knee arthroplasty: A randomized, double-blind, placebo-controlled trial. JBJS. 2018 Jun 4; 3(2):e0006. PMCID: PMC6145559. Link
Muyskens JB et al. Cellular and morphological changes with EAA supplementation before and after total knee arthroplasty. J Appl Physiol. 2019 Aug 1; 127(2):531-545. PMCID: PMC6732445. Link
Muyskens JB et al. Essential amino acid supplementation alters the p53 transcriptional response and cytokine gene expression following total knee arthroplasty. J Appl Physiol. 2020 Oct 1; 129(4):980-991. PMCID: PMC7654691. Link
Jerabek SA et al. Paper #878. Presented at: American Academy of Orthopaedic Surgeons Annual Meeting; March 6-10, 2018; New Orleans. Link
Ueyama H et al. 2020 Chitranjan S. Ranawat Award: Perioperative essential amino acid supplementation suppresses rectus fmoris muscle atrophy and accelerates early functional recovery following total knee arthroplasty. Bone Joint J. 2020 Jun; 102-B(6_Supple_A):10-18. PMID: 32475274. Link
Ueyama H et al. Perioperative essential amino acid supplementation facilitates quadriceps muscle strength and volume recovery after TKA: A double-blinded randomized controlled trial. J Bone Joint Surg Am. 2023 Mar 1; 105(5):345-353. PMID: 36856692. Link
Baldissarro R et al. The hip functional retrieval after elective surgery may be enhanced by supplemented essential amino acids. Biomed Res Int. 2016; 2016:9318329. PMCID: PMC4823478. Link
